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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2005 3
2006 4
2007 1
2010 1
2011 1
2012 1
2013 1
2014 1
2015 1
2016 1
2017 1
2018 2
2019 6
2020 2
2021 2
2022 3
2023 2
2024 0

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30 results

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Page 1
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujić-Čomić H, Fr… See abstract for full author list ➔ Kunkle BW, et al. Nat Genet. 2019 Mar;51(3):414-430. doi: 10.1038/s41588-019-0358-2. Epub 2019 Feb 28. Nat Genet. 2019. PMID: 30820047 Free PMC article.
We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. ...
We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (AD …
Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury.
Schrimpf C, Xin C, Campanholle G, Gill SE, Stallcup W, Lin SL, Davis GE, Gharib SA, Humphreys BD, Duffield JS. Schrimpf C, et al. J Am Soc Nephrol. 2012 May;23(5):868-83. doi: 10.1681/ASN.2011080851. Epub 2012 Mar 1. J Am Soc Nephrol. 2012. PMID: 22383695 Free PMC article.
Kidney pericytes rapidly activated expression of a disintegrin and metalloprotease with thrombospondin motifs-1 (ADAMTS1) and downregulated its inhibitor, tissue inhibitor of metalloproteinase 3 (TIMP3) in response to injury. Similarly to brain pericytes, kidney per …
Kidney pericytes rapidly activated expression of a disintegrin and metalloprotease with thrombospondin motifs-1 (ADAMTS1) and downreg …
ADAMTS1 as potential prognostic biomarker promotes malignant invasion of glioma.
Wang S, Zhang J, Wang K, Zhao Y, Liu D. Wang S, et al. Int J Clin Oncol. 2023 Jan;28(1):52-68. doi: 10.1007/s10147-022-02268-9. Epub 2022 Nov 12. Int J Clin Oncol. 2023. PMID: 36371587
Previous evidence indicated that the matrix metalloproteinase ADAMTS1 was implicated in the process of tumor invasion, but the involvement of ADAMTS1 in glioma malignant invasion remains poorly understood. ...The animal experiment was performed in an intracranial or …
Previous evidence indicated that the matrix metalloproteinase ADAMTS1 was implicated in the process of tumor invasion, but the involv …
Re-Exploring the Inflammation-Related Core Genes and Modules in Cerebral Ischemia.
Lv W, Jiang J, Xu Y, Chen Z, Wang Z, Xing A, Zheng X, Qu T, Wan Q. Lv W, et al. Mol Neurobiol. 2023 Jun;60(6):3439-3451. doi: 10.1007/s12035-023-03275-1. Epub 2023 Mar 3. Mol Neurobiol. 2023. PMID: 36867343
Among them, Atf3, Timp1, Cd14, Lgals3, Hmox1, Ccl2, Emp1, Ch25h, Hspb1, Adamts1, Cd44, Icam1, Anxa2, Rgs1, and Vim showed significant increases in both mouse and rat datasets. (2) Ischemic treatment and reperfusion time were the main confounding factors in gene profile cha …
Among them, Atf3, Timp1, Cd14, Lgals3, Hmox1, Ccl2, Emp1, Ch25h, Hspb1, Adamts1, Cd44, Icam1, Anxa2, Rgs1, and Vim showed significant …
Relevance of IGFBP2 proteolysis in glioma and contribution of the extracellular protease ADAMTS1.
Martino-Echarri E, Fernández-Rodríguez R, Bech-Serra JJ, Plaza-Calonge Mdel C, Vidal N, Casal C, Colomé N, Seoane J, Canals F, Rodríguez-Manzaneque JC. Martino-Echarri E, et al. Oncotarget. 2014 Jun 30;5(12):4295-304. doi: 10.18632/oncotarget.2009. Oncotarget. 2014. PMID: 24962328 Free PMC article.
Using gene expression public databases, we confirmed that IGFBP2 is a poor prognosis marker for gliomas, and we also observed an important contribution of ADAMTS1.Finally, we showed the impact of ADAMTS1 on IGFII-mediated IGF1R phosphorylation and cellular migration …
Using gene expression public databases, we confirmed that IGFBP2 is a poor prognosis marker for gliomas, and we also observed an important c …
Exploring Potential Biomarkers Underlying the Pathogenesis of Alzheimer's Disease by Bioinformatics Gene Analysis.
Ma X, Meng G, Zhang M, Zhao Y, Zhou Y, Zhao Y, Liu X. Ma X, et al. Ann Clin Lab Sci. 2021 Mar;51(2):198-205. Ann Clin Lab Sci. 2021. PMID: 33941559
Subsequently, the data were analyzed using a combined bioinformatics approach and predicted the microRNAs (miRNAs) targeting the key gene using miRNA databases. Based on the results of these analyses, ADAMTS1, CITED2, and GABRA2 were identified as co-DEGs. They were all as …
Subsequently, the data were analyzed using a combined bioinformatics approach and predicted the microRNAs (miRNAs) targeting the key gene us …
Matrix metalloproteinases (MMPs) in health and disease: an overview.
Malemud CJ. Malemud CJ. Front Biosci. 2006 May 1;11:1696-701. doi: 10.2741/1915. Front Biosci. 2006. PMID: 16368548 Review.
In addition, development of MMP null mice carrying specific MMP deletions has provided an opportunity to explore the role of MMPs in normal development as well as in such diverse conditions and diseases as skeletal dysplasias, coronary artery and heart disease, arthritis, …
In addition, development of MMP null mice carrying specific MMP deletions has provided an opportunity to explore the role of MMPs in normal …
Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration.
Tan MS, Yang YX, Xu W, Wang HF, Tan L, Zuo CT, Dong Q, Tan L, Suckling J, Yu JT; Alzheimer’s Disease Neuroimaging Initiative. Tan MS, et al. Alzheimers Res Ther. 2021 Jan 8;13(1):15. doi: 10.1186/s13195-020-00755-7. Alzheimers Res Ther. 2021. PMID: 33419465 Free PMC article.
We examined the association of AD risk allele carrier status with the levels of gene expression in blood and brain regions and tested the association with brain amyloidosis, tauopathy, and neurodegeneration at baseline, using a multivariable linear regression model. …
We examined the association of AD risk allele carrier status with the levels of gene expression in blood and brain regions and tested …
Proteases Upregulation in Sporadic Alzheimer's Disease Brain.
Medoro A, Bartollino S, Mignogna D, Marziliano N, Porcile C, Nizzari M, Florio T, Pagano A, Raimo G, Intrieri M, Russo C. Medoro A, et al. J Alzheimers Dis. 2019;68(3):931-938. doi: 10.3233/JAD-181284. J Alzheimers Dis. 2019. PMID: 30814362
In this study we evaluated the cerebral expression of eight proteases, involved in both AbetaPP processing and extracellular matrix remodeling. Among these proteases, ADAM10, ADAMTS1, Cathepsin D, and Meprin beta show a significantly higher mRNAs expression in sporadic AD …
In this study we evaluated the cerebral expression of eight proteases, involved in both AbetaPP processing and extracellular matrix remodeli …
Development and validation of a prognostic gene expression signature for lower-grade glioma following surgery and adjuvant radiotherapy.
Qian DC, Marascio JA, Tobillo R, Lorenz JW, McCall NS, Neill SG, Hoang KB, Olson JJ, Eaton BR, Shu HG, Zhong J. Qian DC, et al. Radiother Oncol. 2022 Oct;175:93-100. doi: 10.1016/j.radonc.2022.08.020. Epub 2022 Aug 23. Radiother Oncol. 2022. PMID: 35998839 Clinical Trial.
The genes comprising GRS are involved in MAP kinase activity, T cell chemotaxis, and cell cycle transition: MAP3K15, MAPK10, CCL3, CCL4, and ADAMTS1. High GRS, defined as having a GRS in the top third, was significantly associated with poorer outcomes independent of age, s …
The genes comprising GRS are involved in MAP kinase activity, T cell chemotaxis, and cell cycle transition: MAP3K15, MAPK10, CCL3, CCL4, and …
30 results